Description

Amoxicillin Diketopiperazine (Mixture Of Diastereomers) is a key pharmaceutical intermediate derived from the β-lactam antibiotic amoxicillin. This compound is of significant interest for its role in the research and development of novel antibiotic derivatives and for studying degradation pathways. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and academic research institutions focused on antimicrobial agents and drug stability.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of new amoxicillin analogs and related β-lactam compounds.
• Degradation Product Studies: Used as a reference standard to analyze and quantify the formation of diketopiperazine derivatives in amoxicillin formulations, crucial for stability testing.
• Antibiotic Research: Employed in biochemical and microbiological research to investigate structure-activity relationships (SAR) and mechanisms of antibiotic action and resistance.
• Quality Control & Analytical Standards: Acts as an impurity standard in HPLC and other chromatographic methods to ensure the purity and safety of amoxicillin Active Pharmaceutical Ingredients (APIs) and finished drug products.
• Process Chemistry Development: Used in optimizing synthesis and purification processes for amoxicillin to minimize the formation of this and related by-products.

Basic Information

Product Name	Amoxicillin Diketopiperazine (Mixture Of Diastereomers)
CAS No.	94659-47-9
Molecular Formula	C16H19N3O5S
Molecular Weight	365.40 g/mol
Synonyms	(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid cyclic dimer; Diketopiperazine derivative of Amoxicillin; Amoxicillin DKP; Amoxicillin cyclic dipeptide; Amoxicillin anhydride; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, cyclic dimer; Amoxicillin impurity
EINECS	Contact for details

Quality Control

Our Amoxicillin Diketopiperazine is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0% (sum of diastereomers)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.