Description

Nadolol D9 is a deuterium-labeled analog of the β-adrenergic blocker Nadolol, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in the quantification of Nadolol in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in stable isotope dilution assays to study the absorption, distribution, metabolism, and excretion (ADME) of Nadolol.
• Pharmaceutical Quality Control: Employed in analytical method development and validation for the assay and impurity profiling of Nadolol in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Clinical Research: Facilitates accurate therapeutic drug monitoring (TDM) and clinical trial sample analysis for Nadolol.
• Forensic Toxicology: Aids in the precise identification and quantification of Nadolol in forensic investigations.

Basic Information

Product Name	Nadolol D9
CAS No.	94513-92-5
Molecular Formula	C17H20D9NO4
Molecular Weight	312.43 g/mol
Synonyms	5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediol-d9; Nadolol-(phenyl-d9); 2,3-Cis-1-(tert-butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2-propanol-d9; SQ 11725-d9; Corgard-d9; Solgol-d9; Anabet-d9
EINECS	Contact for details

Quality Control

Our Nadolol D9 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment, and chemical purity. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance and traceability in your critical analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.