Description

tert-Butyl N~5~-[(4-Methylphenyl)Sulfonyl]-L-Ornithinate is a protected ornithine derivative, a crucial building block in advanced organic synthesis. This compound is valued for its role as a key chiral intermediate, enabling the controlled construction of complex peptide and peptidomimetic structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified ornithine residues into peptide chains.
• Bioconjugation Chemistry: Serves as a precursor for creating linkers or handles for bioconjugation applications in drug delivery systems.
• Chemical Biology Research: Employed in the synthesis of probes and tools for studying protein-protein interactions and cellular processes.
• Protecting Group Strategy: The tert-butyl ester and tosyl (p-toluenesulfonyl) groups provide orthogonal protection for the amino and carboxyl functionalities during multi-step syntheses.

Basic Information

Product Name	tert-Butyl N~5~-[(4-Methylphenyl)Sulfonyl]-L-Ornithinate
CAS No.	94374-22-8
Molecular Formula	C16H25N2O4S
Molecular Weight	341.45 g/mol
Synonyms	L-Ornithine, N5-[(4-methylphenyl)sulfonyl]-, 1,5-di-tert-butyl ester; tert-Butyl N5-(p-toluenesulfonyl)-L-ornithinate; N(omega)-Tosyl-L-ornithine tert-butyl ester; Nδ-Tosyl-L-ornithine tert-butyl ester; Boc-Orn(Tos)-OtBu (Note: Common abbreviation, though Boc refers to tert-butoxycarbonyl); H-Orn(Tos)-OtBu; (S)-2-amino-5-((4-methylphenyl)sulfonamido)pentanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl N~5~-[(4-Methylphenyl)Sulfonyl]-L-Ornithinate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.