Description

4-(2,3-Bis(Bis(Carboxymethylamino))Propyl)Phenyl Isothiocyanate is a specialized bifunctional chelating agent that incorporates both an isothiocyanate group and multiple carboxymethylamino (iminodiacetic acid) moieties. This compound is critically important for creating stable, site-specific conjugates with biomolecules, enabling advanced applications in diagnostics and targeted therapies. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and medical diagnostics sectors for developing novel radiopharmaceuticals, immunoassays, and targeted drug delivery systems.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for radiolabeling antibodies, peptides, and other targeting vectors with diagnostic (e.g., 99mTc, 111In) or therapeutic (e.g., 177Lu, 90Y) radioisotopes.
• Immunoconjugate Development: Used to create stable covalent linkages between monoclonal antibodies and chelated metal ions for use in radioimmunotherapy (RIT) and radioimmunoimaging.
• Diagnostic Kit Formulation: A key intermediate in the synthesis of reagents for in-vitro diagnostic (IVD) kits, particularly in chemiluminescence and fluorescence-based assays.
• Protein & Peptide Labeling: Facilitates the site-specific attachment of metal chelates to proteins and peptides via the reactive isothiocyanate group, which binds to amine residues.
• Research Tool in Molecular Imaging: Employed in preclinical research for developing novel probes for SPECT and PET imaging.
• Contrast Agent Synthesis: Serves as a building block for synthesizing next-generation MRI contrast agents with improved targeting and clearance profiles.

Basic Information

Product Name	4-(2,3-Bis(Bis(Carboxymethylamino))Propyl)Phenyl Isothiocyanate
CAS No.	94344-71-5
Molecular Formula	C19H26N4O8S
Molecular Weight	470.50 g/mol
Synonyms	4-[2,3-Bis[bis(carboxymethyl)amino]propyl]phenyl isothiocyanate; DTPA-Phenyl-Isothiocyanate derivative; Bifunctional DTPA Isothiocyanate; p-Isothiocyanatobenzyl-DTPA; 4-(p-Isothiocyanatobenzyl)diethylenetriaminepentaacetic acid; Benzyl-Isothiocyanate-DTPA; SC-Bn-DTPA; Chelator-IsoT
EINECS	Contact for details

Quality Control

Our 4-(2,3-Bis(Bis(Carboxymethylamino))Propyl)Phenyl Isothiocyanate is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and production applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.