Description

3-[[n-(3-Amino-2,4,6-Triiodophenyl)-n-Methylamino]Carbonyl]Propionic Acid is a specialized iodinated organic compound that serves as a critical intermediate in the synthesis of advanced contrast media. Its molecular structure, featuring a triiodinated aromatic ring, is engineered for high X-ray attenuation, making it indispensable for creating safe and effective diagnostic agents. This high-purity intermediate is primarily required by pharmaceutical manufacturers and fine chemical synthesis facilities developing next-generation non-ionic, low-osmolar radiographic contrast media for computed tomography (CT) and angiography.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of non-ionic X-ray contrast agents like iopamidol, iohexol, and ioversol.
• Diagnostic Imaging: Production of active pharmaceutical ingredients (APIs) used in CT scans, urography, and vascular imaging procedures.
• Fine Chemical Synthesis: Valuable precursor in organic synthesis for introducing iodinated aromatic structures into complex molecules.
• Research & Development: Used in academic and industrial R&D for developing novel iodinated compounds with potential diagnostic or therapeutic applications.
• Contrast Media Formulation: Integral to manufacturing processes that require high-purity, chemically defined intermediates to ensure final product safety and efficacy.

Basic Information

Product Name	3-[[n-(3-Amino-2,4,6-Triiodophenyl)-n-Methylamino]Carbonyl]Propionic Acid
CAS No.	1221-05-2
Molecular Formula	C11H11I3N2O3
Molecular Weight	615.93 g/mol
Synonyms	5-Amino-2,4,6-triiodo-N-methyl-N-(2-carboxyethyl)isophthalamic Acid; 3-[[(3-Amino-2,4,6-triiodophenyl)methylamino]carbonyl]propanoic Acid; ADTP; Iopamidol Intermediate; Iohexol Intermediate; 1221-05-2; 5-Amino-2,4,6-triiodo-N-methylisophthalamic acid-β-alanine
EINECS	Contact for details

Quality Control

Our 3-[[n-(3-Amino-2,4,6-Triiodophenyl)-n-Methylamino]Carbonyl]Propionic Acid is manufactured under strict quality management systems. Production adheres to current Good Manufacturing Practice (cGMP) principles suitable for pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and impurity profile, identity confirmation by IR, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.