Description

Sodium 3-(Acetylamino)-2,4,6-Triiodo-5-[(Methylamino)Carbonyl]Benzoate is a high-purity, iodinated organic compound primarily used as a key intermediate in the synthesis of X-ray contrast media. Its value lies in its precise chemical structure, which is critical for producing safe and effective diagnostic agents for medical imaging. This product is essential for pharmaceutical manufacturers and advanced research facilities focused on developing and producing non-ionic, low-osmolar contrast agents.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of iopamidol, ioversol, and other non-ionic X-ray contrast media.
• Contrast Agent Production: Serves as a precursor in multi-step synthesis processes to create final injectable formulations for computed tomography (CT) and angiography.
• Research & Development: Used in academic and industrial R&D for developing new iodinated contrast molecules with improved safety profiles.
• Chemical Synthesis: Employed in specialized organic synthesis for introducing the triiodobenzene core into complex molecules.
• Quality Control Reference: Acts as a reference standard for analytical methods in pharmaceutical quality control laboratories.

Basic Information

Product Name	Sodium 3-(Acetylamino)-2,4,6-Triiodo-5-[(Methylamino)Carbonyl]Benzoate
CAS No.	1225-20-3
Molecular Formula	C11H9I3N2NaO4
Molecular Weight	669.90 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-methylisophthalamic Acid Sodium Salt; Sodium 5-Acetamido-2,4,6-triiodo-N-methylisophthalamate; Iopamidol Intermediate; Ioversol Intermediate; AD-01; AD 01; Sodium Salt of Iopamidol Acid; Benzoic acid, 3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]-, sodium salt (1:1)
EINECS	214-949-9

Quality Control

Our Sodium 3-(Acetylamino)-2,4,6-Triiodo-5-[(Methylamino)Carbonyl]Benzoate is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. We offer material compliant with ICH Q7 guidelines and can support customer audits. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents. Specifications can be aligned with customer-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.