Description

Meosuc-Ala-Ala-Pro-Boroval-Pinacol is a specialized synthetic peptide derivative containing a boronic acid pinacol ester functional group. This compound is of significant interest in medicinal chemistry and biochemistry research, particularly in the development of protease inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in the design and synthesis of targeted covalent inhibitors for enzymes such as proteasomes and serine proteases.

Application

• Protease Inhibitor Research: Serves as a key intermediate or active pharmacophore in the development of covalent, reversible inhibitors targeting specific proteolytic enzymes.
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and the synthesis of novel therapeutic candidates for conditions like cancer, inflammation, and infectious diseases.
• Biochemical Tool Development: Employed in the creation of activity-based probes (ABPs) for labeling and studying the activity of specific proteases in complex biological systems.
• Pharmaceutical Intermediate: Acts as a critical building block in the multi-step synthesis of advanced, boronic acid-based active pharmaceutical ingredients (APIs).
• Enzyme Mechanism Studies: Facilitates research into the catalytic mechanisms and inhibition kinetics of serine proteases and other hydrolytic enzymes.

Basic Information

Product Name	Meosuc-Ala-Ala-Pro-Boroval-Pinacol
CAS No.	94242-92-9
Molecular Formula	C₂₀H₃₄BN₃O₇
Molecular Weight	439.31 g/mol
Synonyms	N-[(2S)-1-[[(1S)-1-[[(2S)-1-[(3aS,4S,6S,7aR)-3a,5,5-Trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylsulfanyl)butanediamide; MeOSuc-Ala-Ala-Pro-BoroVal-Pin; (S)-2-((S)-2-((S)-1-((3aS,4S,6S,7aR)-3a,5,5-Trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl)butanamido)-3-methylbutanamido)-3-methylbutanamido)-3-(methylthio)butanoic Acid; Boronate Peptide Inhibitor; Proteasome Inhibitor Intermediate.
EINECS	Contact for details

Quality Control

Our Meosuc-Ala-Ala-Pro-Boroval-Pinacol is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines suitable for non-GMP research materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.