Description

[Acetyl(4-Fluorophenyl)]Acetic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of a fluorine atom can dramatically alter biological activity and metabolic stability. It is primarily required by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine moiety enhances efficacy and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for fluorinated organic electronic materials requiring specific dipole moments and stability.
• Peptidomimetics & Bio-conjugation: The acetic acid moiety allows for coupling reactions in peptide chemistry and the creation of targeted bioconjugates.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new fluorination strategies and novel compound libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke fluorinated intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	[Acetyl(4-Fluorophenyl)]Acetic Acid
CAS No.	93962-54-0
Molecular Formula	C10H9FO3
Molecular Weight	196.18 g/mol
Synonyms	2-(4-Fluorophenyl)-3-oxobutanoic Acid; 4-Fluorophenylacetylacetic Acid; 3-Oxo-2-(4-fluorophenyl)butanoic Acid; α-Acetyl-4-fluorophenylacetic Acid; (4-Fluorophenyl)acetoacetic Acid; 2-Acetyl-2-(4-fluorophenyl)acetic Acid; 4-Fluoro-α-acetylbenzeneacetic Acid
EINECS	Contact for details

Quality Control

Our [Acetyl(4-Fluorophenyl)]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets precise customer specifications. Certificates of Analysis (COA) with full traceability are provided for every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong bases, oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	102 - 106 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.