Description

(R)-[[(Allyloxy)Carbonyl]Amino](3-Chloro-4-Hydroxyphenyl)Acetic Acid is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the development of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs), particularly in therapeutic areas requiring high stereochemical control.
• Peptide Synthesis: Used in the preparation of modified amino acids and peptide analogs, where the (R)-configuration and protected functional groups are essential.
• Agrochemical Research: Serves as a precursor in the development of chiral herbicides, fungicides, and plant growth regulators with enhanced activity and selectivity.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Utilized in the creation of molecular probes and labeled compounds for studying biological pathways and mechanisms.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects requiring specific chirality and functional group compatibility.

Basic Information

Product Name	(R)-[[(Allyloxy)Carbonyl]Amino](3-Chloro-4-Hydroxyphenyl)Acetic Acid
CAS No.	93841-52-2
Molecular Formula	C12H12ClNO5
Molecular Weight	285.68 g/mol
Synonyms	(R)-2-[[(Allyloxy)carbonyl]amino]-2-(3-chloro-4-hydroxyphenyl)acetic acid; (R)-N-[(Allyloxy)carbonyl]-3-chloro-4-hydroxyphenylglycine; (R)-Alloc-3-chloro-4-hydroxy-phenylglycine; (R)-N-Alloc-3-chloro-4-hydroxyphenylglycine; (R)-2-((Allyloxycarbonyl)amino)-2-(3-chloro-4-hydroxyphenyl)acetic acid; (R)-ACHA; (R)-N-Alloc-Chlorotyrosine derivative
EINECS	Contact for details

Quality Control

Our production of (R)-[[(Allyloxy)Carbonyl]Amino](3-Chloro-4-Hydroxyphenyl)Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized and tested using advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.