Description

Artemether-D3 is a deuterium-labeled analog of the potent antimalarial drug artemether, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity reference material is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolic research, particularly in drug development and therapeutic monitoring. It is an essential tool for analytical laboratories and pharmaceutical R&D teams requiring precise mass spectrometry-based quantification.

Application

• Internal Standard for LC-MS/MS: Primary use as a stable isotope-labeled internal standard for the accurate quantification of artemether and its metabolites in biological matrices (plasma, serum, tissue).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise studies on the absorption, distribution, metabolism, and excretion (ADME) profile of artemether.
• Bioanalytical Method Development & Validation: Critical for developing and validating robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Research: Supports therapeutic drug monitoring and clinical trial sample analysis to ensure patient safety and efficacy data integrity.
• Pharmaceutical Quality Control: Used in advanced analytical techniques to assess drug product quality and stability.

Basic Information

Product Name	Artemether-D3
CAS No.	93787-85-0
Molecular Formula	C16H23D3O5
Molecular Weight	301.40 g/mol
Synonyms	Artemether-d3; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-d3; Dihydroartemisinin methyl ether-d3; (+)-Artemether-d3; [2H3]-Artemether
EINECS	Contact for details

Quality Control

Our Artemether-D3 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic methods. We support compliance with relevant pharmacopeial and ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.