Description

3-Methoxy-α-[(Trimethylsilyl)Oxy]-Benzeneacetonitrile is a versatile silyl-protected cyanohydrin derivative, a key synthetic intermediate in modern organic chemistry. Its primary value lies in its role as a protected form of a mandelonitrile derivative, enabling complex multi-step syntheses under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug molecules, especially those containing chiral benzylic centers.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry is required.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other specialty organic compounds.
• Chiral Synthesis: The protected cyanohydrin group is valuable for asymmetric synthesis and the preparation of enantiomerically pure compounds.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and catalysis research.
• Material Science Precursor: Potential use in the synthesis of monomers or ligands for advanced polymeric or coordination materials.

Basic Information

Product Name	3-Methoxy-α-[(Trimethylsilyl)Oxy]-Benzeneacetonitrile
CAS No.	93554-98-4
Molecular Formula	C₁₂H₁₇NO₂Si
Molecular Weight	235.36 g/mol
Synonyms	2-(3-Methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile; (3-Methoxyphenyl)(trimethylsilyloxy)acetonitrile; α-(Trimethylsiloxy)-3-methoxybenzeneacetonitrile; O-Trimethylsilyl-3-methoxymandelonitrile; 3-Methoxy-α-(trimethylsiloxy)phenylacetonitrile; TMS-protected 3-methoxymandelonitrile
EINECS	Contact for details

Quality Control

Our 3-Methoxy-α-[(Trimethylsilyl)Oxy]-Benzeneacetonitrile is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.