Description

o-Tert·Butyl-trans-4-Hydroxy-L-Prolinetert·Butyl CAS NO 93527-54-9 is a high-purity, protected amino acid derivative primarily used as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemical control in the construction of complex molecules. It is particularly valuable for the pharmaceutical industry in the development of peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected hydroxyproline moiety.
• Medicinal Chemistry Research: Serves as a building block for creating focused libraries and exploring structure-activity relationships (SAR).
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective reactions.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Useful for synthesizing labeled or modified peptides for biochemical studies.

Basic Information

Product Name	o-Tert·Butyl-trans-4-Hydroxy-L-Prolinetert·Butyl
CAS No.	93527-54-9
Molecular Formula	C13H25NO3
Molecular Weight	243.34 g/mol
Synonyms	(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxyproline tert-butyl ester; (2S,4R)-4-Hydroxy-1-[(2-methyl-2-propanyl)oxycarbonyl]-2-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; Boc-trans-4-hydroxy-L-proline tert-butyl ester; Boc-Hyp(OtBu)-OH; Boc-Hyp(OtBu); trans-4-Hydroxy-L-proline, N-Boc, O-t-butyl ester; (2S,4R)-1-(Boc)-4-(t-butoxy)-L-proline; N-Boc-trans-4-hydroxy-L-proline tert-butyl ester
EINECS	Contact for details

Quality Control

Our o-Tert·Butyl-trans-4-Hydroxy-L-Prolinetert·Butyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.