Description

Xamoterol β-D-Glucuronide is a high-purity biochemical reference standard and metabolite of the β-adrenergic receptor partial agonist, xamoterol. This compound is critical for analytical research and development, providing a definitive benchmark for quantification and method validation. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism, pharmacokinetic studies, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the calibration of analytical instruments and validation of assay methods in drug development.
• Metabolite Identification & Profiling: Used as an authentic standard in LC-MS and HPLC analyses to identify and quantify xamoterol metabolites in biological matrices.
• Bioanalytical Method Development: Essential for developing and optimizing sensitive and specific analytical methods for pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Quality Control & Assurance: Employed in the quality control testing of active pharmaceutical ingredients (APIs) and finished drug products to ensure purity and consistency.
• Regulatory Submissions: Provides necessary data and reference materials for regulatory filings with agencies such as the FDA and EMA.
• Academic & Clinical Research: Supports fundamental research on β-adrenergic receptor pharmacology and the metabolic pathways of related therapeutics.

Basic Information

Product Name	Xamoterol β-D-Glucuronide
CAS No.	93491-13-5
Molecular Formula	C22H34N2O9
Molecular Weight	470.52 g/mol
Synonyms	Xamoterol Glucuronide; Xamoterol β-D-Glucopyranosiduronic Acid; Xamoterol 1-O-β-D-Glucuronide; 4-[2-[[(2R)-2-(3,4-Dimethoxyphenoxy)ethyl]amino]-1-hydroxyethyl]-2-methoxyphenyl β-D-Glucopyranosiduronic Acid; Xamoterol Metabolite; Corwin Glucuronide; ICI 118587 Glucuronide
EINECS	Contact for details

Quality Control

Our Xamoterol β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for use as a reference material. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.