Description

Substance P (4-11), Pro(4)-Npa(7,9)-Phe(11)- is a specific, biologically active fragment of the neuropeptide Substance P, identified by CAS NO 93490-35-8. This compound is a critical research tool for investigating the structure-activity relationships of Substance P, particularly its interaction with neurokinin receptors. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and peptide-based drug discovery who require high-purity, well-characterized analogs for receptor binding studies and functional assays.

Application

• Neuroscience Research: Used as a selective ligand to study the physiological and pathological roles of Substance P fragments in the central and peripheral nervous systems.
• Pharmacological Assays: Employed in competitive binding studies and functional assays to characterize neurokinin receptor subtypes (NK1, NK2, NK3) and screen for potential antagonists.
• Structure-Activity Relationship (SAR) Studies: Serves as a key analog to map the bioactive core of Substance P and understand the contribution of specific amino acid residues to receptor affinity and selectivity.
• Biochemical Tool Development: Utilized in the development of diagnostic kits and research reagents for studying inflammation, pain transmission, and neurogenic processes.
• Academic & Pharmaceutical R&D: A fundamental reagent for universities, research institutes, and pharmaceutical companies engaged in peptide therapeutics and neuropeptide research.

Basic Information

Product Name	Substance P (4-11), Pro(4)-Npa(7,9)-Phe(11)-
CAS No.	93490-35-8
Molecular Formula	C55H78N14O11
Molecular Weight	1087.3 g/mol
Synonyms	Substance P Fragment 4-11; [Pro4, Npa7,9, Phe11]-Substance P (4-11); [pGlu6, Npa7,9, Phe11]-Substance P (6-11); Arg-Pro-Lys-Pro-Npa-Gln-Npa-Phe; Neurokinin P fragment; SP (4-11) analog; Tachykinin peptide fragment
EINECS	Contact for details

Quality Control

Our Substance P (4-11) analog is produced under stringent quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques including HPLC, MS, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.