Description

Conantokin G is a selective and potent antagonist of the N-methyl-D-aspartate (NMDA) receptor, specifically targeting the NR2B subunit. This compound is a critical research tool for neuropharmacological studies, enabling the investigation of excitatory neurotransmission, synaptic plasticity, and neurological disorders. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies focused on CNS drug discovery and basic neuroscience research.

Application

• Neuroscience Research: A fundamental tool for studying the role of NMDA receptors, particularly the NR2B subtype, in synaptic transmission, long-term potentiation (LTP), and long-term depression (LTD).
• Neuropharmacology: Used to characterize and validate novel compounds targeting the NMDA receptor complex in drug discovery pipelines for conditions like stroke, chronic pain, and neurodegenerative diseases.
• Mechanistic Studies: Employed in electrophysiology (patch-clamp) and calcium imaging experiments to isolate and understand NR2B-mediated currents and signaling pathways.
• Biochemical Assays: Serves as a reference standard in receptor binding assays and high-throughput screening (HTS) campaigns to identify new modulators of ionotropic glutamate receptors.
• Toxicology & Safety Pharmacology: Used to model excitotoxicity and investigate mechanisms of neuronal cell death, contributing to safety assessment profiles of new chemical entities.

Basic Information

Product Name	Conantokin G
CAS No.	93438-65-4
Molecular Formula	C95H148N34O27
Molecular Weight	2294.4 g/mol
Synonyms	Con-G; Conantokin-G; γ-carboxyglutamate-containing peptide; NMDA receptor antagonist conantokin-G; NR2B-selective conantokin; Snail venom peptide conantokin G
EINECS	Contact for details

Quality Control

Our Conantokin G is produced under stringent quality management systems. Each batch undergoes comprehensive analytical characterization, including purity assessment by HPLC, mass spectrometry for identity confirmation, and endotoxin testing. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and support your research compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Biological Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.