Description

H-Gly-Gly-His-Oh H2O is a high-purity tripeptide derivative, specifically the hydrated form of the glycyl-glycyl-histidine sequence. This compound is valued for its role as a biochemical building block and a model system for studying metal-peptide interactions, particularly with copper. It is essential for researchers and manufacturers in the fields of biochemistry, pharmaceutical development, and advanced material science.

Application

• Biochemical Research: Used as a model peptide to study copper-binding kinetics, antioxidant mechanisms, and peptide-metal coordination chemistry.
• Pharmaceutical Intermediates: Serves as a key precursor or intermediate in the synthesis of more complex therapeutic peptides and diagnostic agents.
• Cosmetic & Skincare Actives: Incorporated into formulations for its potential antioxidant and metal-chelating properties, which may help protect skin from oxidative stress.
• Nutraceutical Development: Investigated for use in dietary supplements targeting oxidative balance, leveraging its natural histidine-containing structure.
• Catalyst & Material Science: Acts as an organic ligand or template in the development of bio-inspired catalysts and functional nanomaterials.
• Reference Standard: Employed as a certified reference material (CRM) for analytical method development and quality control in peptide analysis.

Basic Information

Product Name	H-Gly-Gly-His-Oh H2O
CAS No.	93404-95-6
Molecular Formula	C11H17N5O5 • xH2O
Molecular Weight	299.29 g/mol (anhydrous basis)
Synonyms	Glycyl-glycyl-L-histidine; GGH; H-Gly-Gly-His-OH hydrate; L-Histidylglycylglycine; NSC 334916; Gly-Gly-His; Tripeptide GGH; Copper-binding peptide GGH; 2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoic acid hydrate
EINECS	Contact for details

Quality Control

Our H-Gly-Gly-His-Oh H2O is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, water content, and residual solvents. Our quality commitment supports applications requiring research-grade to GMP-standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 8.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.