Description

(tert-Butoxy)Carbonyl Phe-D-Phe-Oh is a protected dipeptide building block of significant importance in synthetic organic and medicinal chemistry. Its core value lies in enabling the precise, stereocontrolled synthesis of complex peptide sequences, particularly those incorporating D-amino acids for enhanced metabolic stability. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel peptide-based therapeutics, diagnostic agents, and biochemical tools. Its defined chiral center and protective group offer critical control over reaction pathways and final product integrity.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Protease Inhibitor Development: Used in constructing substrate analogs and inhibitors targeting specific enzymes like HIV protease or renin.
• Bioconjugation & Probe Synthesis: Serves as a chiral spacer or linker in the creation of labeled peptides for imaging, diagnostics, and affinity studies.
• Academic & R&D: Fundamental reagent for studying peptide structure-activity relationships (SAR), chiral recognition, and novel synthetic methodologies.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive molecules.

Basic Information

Product Name	(tert-Butoxy)Carbonyl Phe-D-Phe-Oh
CAS No.	93397-22-9
Molecular Formula	C21H24N2O5
Molecular Weight	384.43 g/mol
Synonyms	Boc-Phe-D-Phe-OH; Boc-L-Phe-D-Phe-OH; N-(tert-Butoxycarbonyl)-L-phenylalanyl-D-phenylalanine; N-Boc-L-phenylalanyl-D-phenylalanine; (2R)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid; Boc-Phe-ψ[CH2NH]-D-Phe-OH (reduced peptide bond analog); Nα-Boc-L-Phenylalanyl-D-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of (tert-Butoxy)Carbonyl Phe-D-Phe-Oh is produced under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality protocol includes HPLC for assay and chiral purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) documenting these results is provided with each shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (D-Phe)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.