Description

Botulinum Toxin D is a potent neurotoxin produced by the bacterium *Clostridium botulinum*. This specific serotype is a critical biological tool for advanced neurological research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, muscle disorders, and novel therapeutic applications.

Application

• Neuroscience Research: Fundamental studies on synaptic transmission, neurotransmitter release, and neuronal cell biology.
• Therapeutic Agent Development: Investigation as a potential active pharmaceutical ingredient (API) for treating specific muscular and neurological conditions.
• Cell Biology & Physiology: Used as a precise molecular tool to block exocytosis in various cell types for mechanistic studies.
• Toxicology & Safety Assessment: Serves as a reference standard in potency assays and safety testing for botulinum toxin-based products.
• Biodefense and Antitoxin Research: Critical material for developing and testing neutralizing antibodies and detection assays.

Basic Information

Item	Details
Product Name	Botulinum Toxin D
CAS No.	93384-46-4
Molecular Formula	C6760H10447N1743O2010S40 (Approx., for 150 kDa neurotoxin)
Molecular Weight	~150 kDa (Monomeric neurotoxin)
Synonyms	Botulinum Neurotoxin Type D; BoNT/D; Clostridium Botulinum Toxin Type D; Botulinum Toxin Serotype D; BotD; Neurotoxin D
EINECS	Contact for details

Quality Control

Our Botulinum Toxin D is produced and handled under stringent quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided, which includes data on potency (LD50), purity by SDS-PAGE, sterility, and endotoxin levels, meeting the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or vacuum when possible. Handle in accordance with appropriate biosafety level (BSL-2) practices.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or crystalline solid
Identification (SDS-PAGE)	Corresponds to standard for BoNT/D (~150 kDa band under reducing conditions)
Purity (SDS-PAGE)	≥ 95% (Scanning Densitometry)
Potency (Mouse Bioassay)	≥ 1 x 107 LD50/mg
Protein Content (Bradford)	Reported on COA
Endotoxin (LAL)	< 5.0 EU/mg
Sterility (Membrane Filtration)	Sterile
Solubility	Soluble in appropriate buffers (e.g., PBS with gelatin)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.