Description

n-Cbz-4-Iodoaniline is a protected aniline derivative, specifically an N-carbobenzyloxy (Cbz) protected 4-iodoaniline, serving as a crucial building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine group, allowing for selective reactions on the aromatic ring, particularly via the iodine substituent in cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in developing active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those requiring Suzuki or other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the iodoaniline scaffold is incorporated.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic systems.
• Material Science Research: Employed in the synthesis of organic semiconductors, dyes, and photoactive materials.
• Peptide Chemistry: The Cbz protecting group is cleavable under mild hydrogenation conditions, making it useful in peptide synthesis strategies.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and for constructing molecular libraries.

Basic Information

Product Name	n-Cbz-4-Iodoaniline
CAS No.	93298-14-7
Molecular Formula	C14H12INO2
Molecular Weight	353.16 g/mol
Synonyms	Carbobenzyloxy-4-iodoaniline; N-[(Benzyloxy)carbonyl]-4-iodoaniline; 4-Iodo-N-[(phenylmethoxy)carbonyl]aniline; Benzyl (4-iodophenyl)carbamate; N-Cbz-4-iodo-benzenamine; 1-Iodo-4-[(phenylmethoxy)carbonylamino]benzene; Cbz-4-Iodoaniline; N-(Benzyloxycarbonyl)-4-iodoaniline
EINECS	Contact for details

Quality Control

Our n-Cbz-4-Iodoaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and production. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.