Description

Nalpha-Fmoc-L-Tyrosine CAS NO 92954-90-0 is a protected derivative of the essential amino acid L-tyrosine, featuring a 9-fluorenylmethoxycarbonyl (Fmoc) group on the α-amino nitrogen. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled, sequential assembly of complex peptides and proteins. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in peptide-based drug discovery, therapeutic agent development, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of peptide chains.
• Pharmaceutical Intermediates: For the synthesis of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation & Probe Development: Utilized to incorporate tyrosine residues for subsequent labeling or cross-linking in bioconjugate chemistry.
• Research & Development: Serves as a fundamental reagent in academic and industrial laboratories for studying protein structure-function relationships.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	Nalpha-Fmoc-L-Tyrosine
CAS No.	92954-90-0
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-Tyr-OH; Fmoc-L-Tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tyrosine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-hydroxyphenyl)propanoic acid; N-α-Fmoc-L-tyrosine; Fmoc-Tyrosine; FMOC-L-Tyrosine-OH; N-Fmoc-L-tyrosine
EINECS	Contact for details

Quality Control

Our Nalpha-Fmoc-L-Tyrosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.