Description

Clofilium Tosylate is a high-purity pharmaceutical intermediate and research chemical, specifically the tosylate salt form of the class III antiarrhythmic agent clofilium. This compound is of significant value in the development and synthesis of cardiac electrophysiology research tools and potential therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in cardiovascular drug discovery and development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of clofilium-based antiarrhythmic agents and related chemical entities.
• Biochemical Research: Used as a potent, long-acting blocker of potassium channels (IKr) in cardiac electrophysiology studies.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Mechanistic Studies: Employed in preclinical research to investigate the role of specific ion currents in cardiac action potential duration and arrhythmogenesis.
• Chemical Synthesis: Utilized in organic synthesis for introducing the clofilium pharmacophore into more complex molecules for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Clofilium Tosylate
CAS No.	92953-10-1
Molecular Formula	C28H36ClNO3S
Molecular Weight	502.11 g/mol
Synonyms	4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium 4-methylbenzenesulfonate; Clofilium tosilate; Clofilium p-toluenesulfonate; 4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium p-toluenesulfonate; LY150378; 1-Butanaminium, 4-chloro-N,N-diethyl-N-heptyl-, 4-methylbenzenesulfonate; Clofilium Tosylate Salt
EINECS	Contact for details

Quality Control

Our Clofilium Tosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.