Description

Gadolinium 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetraacetate is a highly stable, macrocyclic gadolinium(III) chelate complex, primarily utilized as a key intermediate and precursor in the development of advanced magnetic resonance imaging (MRI) contrast agents. Its importance lies in its exceptional thermodynamic and kinetic stability, which is critical for creating safer, high-performance diagnostic tools. This product is essential for research institutions, pharmaceutical developers, and fine chemical manufacturers focused on next-generation medical imaging, radiopharmaceuticals, and specialized coordination chemistry applications.

Application

• MRI Contrast Agent Precursor: Serves as the foundational chelate structure for synthesizing next-generation, high-relaxivity gadolinium-based contrast media.
• Radiopharmaceutical Development: Used in research for creating targeted diagnostic and therapeutic agents, where the stable macrocyclic core can be functionalized with targeting vectors.
• Bioconjugation & Probe Synthesis: Acts as a versatile platform for attaching biomolecules (antibodies, peptides) to create molecular imaging probes for research.
• Coordination Chemistry Research: A model compound for studying lanthanide coordination, kinetics, and the design of novel macrocyclic ligands.
• Material Science: Potential use in developing luminescent materials, sensors, or catalysts leveraging gadolinium's unique magnetic and optical properties.
• Quality Control & Reference Standard: Employed as an analytical standard to qualify and benchmark other contrast agent formulations.

Basic Information

Product Name	Gadolinium 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetraacetate
CAS No.	92923-44-9
Molecular Formula	C16H24GdN4O8
Molecular Weight	546.64 g/mol
Synonyms	Gadolinium DOTA; Gd-DOTA; Gadoterate (Gadolinium complex); 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, gadolinium complex; Gadolinium(III) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate; Dotarem® (Active Pharmaceutical Ingredient); Tetraglycineamide, N,N',N'',N'''-tetraacetato(3-)-N,N',N'',N''', gadolinate(1-); Gadolinium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid complex
EINECS	Contact for details

Quality Control

Our Gadolinium DOTA is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, ICP-MS for elemental impurities, and NMR for structural confirmation, to ensure it meets stringent specifications for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with relevant internal standards and supporting its use in GMP-regulated development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Gadolinium Content (ICP-MS)	26.5 - 29.5 %
Free Gadolinium	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.