Description

1-(6-Chloro-9H-Carbazol-2-Yl)Ethanone (Carprofen Impurity) is a high-purity organic compound used as a critical reference standard and impurity marker in pharmaceutical development. Its primary value lies in ensuring the quality, safety, and regulatory compliance of the non-steroidal anti-inflammatory drug (NSAID) Carprofen. This compound is essential for analytical chemists and quality control laboratories within the pharmaceutical and fine chemical industries who require precise materials for method validation, stability studies, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of related substances in Carprofen Active Pharmaceutical Ingredient (API) and finished drug products.
• Impurity Profiling & Characterization: Critical for method development and validation in HPLC, UPLC, and GC analyses to monitor and control specific process-related impurities.
• Stability Indicating Studies: Employed in forced degradation studies to understand the degradation pathways of Carprofen and to validate analytical methods.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive proof of impurity identity and supporting the establishment of specification limits.
• Research & Development: Serves as a key intermediate or impurity standard in the synthetic pathway research and process optimization for carbazole-based pharmaceuticals.
• Quality Control (QC) Testing: An essential tool in routine QC laboratories for batch release testing of Carprofen API to ensure it meets pharmacopeial or internal purity specifications.

Basic Information

Product Name	1-(6-Chloro-9H-Carbazol-2-Yl)Ethanone (Carprofen Impurity)
CAS No.	92841-22-0
Molecular Formula	C14H10ClNO
Molecular Weight	243.69 g/mol
Synonyms	2-Acetyl-6-chlorocarbazole; 6'-Chloro-2'-acetylcarbazole; 6-Chloro-2-acetyl-9H-carbazole; Carprofen Impurity; Carprofen Related Compound A; 1-(6-Chloro-9H-carbazol-2-yl)ethan-1-one
EINECS	Contact for details

Quality Control

Every batch of 1-(6-Chloro-9H-Carbazol-2-Yl)Ethanone is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a reference standard, including identity confirmation by spectroscopic methods and purity determination by chromatographic techniques. A detailed Certificate of Analysis (COA) containing batch-specific results for purity, related substances, and residual solvents is supplied with each shipment to ensure full traceability and compliance with pharmaceutical industry requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to prevent degradation or absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.