Description

L-Glutamic Acid γ-(2,2,2-Trichloroethyl) Ester is a specialized amino acid derivative where the γ-carboxyl group of L-glutamic acid is protected by a 2,2,2-trichloroethyl (Tce) group. This compound is a crucial protected intermediate in peptide synthesis and organic chemistry, offering selective deprotection under mild conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis Intermediate: Serves as a key building block for the solid-phase and solution-phase synthesis of complex peptides, protecting the glutamic acid side chain.
• Pharmaceutical Research & Development: Used in the R&D of therapeutic peptides, hormones, and drug candidates where glutamic acid residues are required.
• Bioconjugation Chemistry: Acts as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Organic Synthesis Reagent: Employed in the synthesis of custom amino acid derivatives, unnatural amino acids, and other fine chemicals.
• Biochemical Research: Utilized in studies of enzyme substrates, receptor ligands, and other biochemical probes.
• Material Science: Potential applications in the development of specialized polymers and biomaterials with peptide-based functionalities.

Basic Information

Item	Details
Product Name	L-Glutamic Acid γ-(2,2,2-Trichloroethyl) Ester
CAS No.	92739-23-6
Molecular Formula	C7H10Cl3NO4
Molecular Weight	278.52 g/mol
Synonyms	L-Glutamic Acid 5-(2,2,2-Trichloroethyl) Ester; (S)-2-Amino-5-((2,2,2-trichloroethoxy)carbonyl)pentanoic Acid; Tce-Glu-OH; γ-(2,2,2-Trichloroethyl) L-Glutamate; 2,2,2-Trichloroethyl L-Glutamate; Glutamic Acid γ-(2,2,2-Trichloroethyl) Ester; L-Glutamic Acid γ-Trichloroethyl Ester; N/A-Protected Glutamic Acid Tce Ester
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid γ-(2,2,2-Trichloroethyl) Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.