Description

n-Desmethyl Noscapine-D3 is a deuterium-labeled internal standard critical for precise quantitative analysis in modern bioanalytical chemistry. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units requiring definitive identification and quantification of its parent compound and metabolites.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of noscapine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in confirmatory testing and method development for the detection of noscapine and related alkaloids.
• Drug Development & Impurity Profiling: Supports method validation and impurity characterization in pharmaceutical quality control and stability testing.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the gold-standard technique for achieving high-accuracy, trace-level measurements in regulatory-compliant environments.

Basic Information

Product Name	n-Desmethyl Noscapine-D3
CAS No.	92621-03-9
Molecular Formula	C₂₁H₁₉D₃NO₇
Molecular Weight	~416.42 g/mol
Synonyms	O-Desmethylnoscapine-d3; 7-O-Desmethylnoscapine-d3; Noscapine Metabolite-d3; Noscapine-d3 Metabolite; 1,2,3,4-Tetrahydro-8-hydroxy-6,7-dimethoxy-1-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-methyl-isoquinolin-3-one-d3; [2H3]-O-Desmethylnoscapine
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Noscapine-D3 is manufactured and analyzed under strict quality management systems to ensure exceptional isotopic purity and chemical identity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.