Description

(-)-n-Formyl-L-tert-Leucine is a high-purity, non-proteinogenic amino acid derivative characterized by its chiral tert-leucine backbone and formyl protecting group. This compound matters as a critical chiral building block and intermediate in the synthesis of complex pharmaceuticals, enabling the production of active pharmaceutical ingredients (APIs) with high stereochemical purity. It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for applications in peptide synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, antiviral drugs, and other bioactive molecules.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide chemistry to introduce the sterically hindered tert-leucine residue.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material for the preparation of enantiomerically pure compounds in medicinal chemistry.
• Bioconjugation & Labeling: The formyl group can be utilized in specific bioconjugation strategies for drug delivery systems or diagnostic agents.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and developing novel therapeutic candidates.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	(-)-n-Formyl-L-tert-Leucine
CAS No.	92571-61-4
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	N-Formyl-L-tert-leucine; (S)-2-Formamido-3,3-dimethylbutanoic acid; L-tert-Leucine, N-formyl-; Fmoc-L-tert-leucine-OH (Note: This is a different, common protected form); Boc-L-tert-leucine-OH (Note: This is a different, common protected form); (S)-2-Formylamino-3,3-dimethyl-butyric acid; N-For-L-tert-Leu-OH; (-)-N-Formyl-L-tert-leucine
EINECS	Contact for details

Quality Control

Our (-)-n-Formyl-L-tert-Leucine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.