Description

p-Cresol Glucuronide Methyl Ester Triacetate is a high-purity, synthetic reference standard and key intermediate in advanced biochemical research and pharmaceutical development. This compound is critical for analytical method development, serving as a validated standard for the quantification of p-cresol metabolites in complex biological matrices. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in metabolic studies, toxicology, and the development of novel therapeutic agents.

Application

• Analytical Reference Standard: Primary use as a certified standard for HPLC, LC-MS, and GC-MS analysis in clinical and research laboratories.
• Biomarker Research: Essential for studying p-cresol sulfate and glucuronide conjugates as uremic toxins in renal function and metabolic disease research.
• Diagnostic Development: Used in the calibration and validation of diagnostic assays and kits designed to measure specific phenolic metabolites.
• Pharmaceutical Intermediate: Serves as a protected synthetic precursor in the development of novel glucuronidated drug candidates or probes.
• Metabolic Pathway Studies: A crucial tool for investigating Phase II metabolism, specifically glucuronidation pathways, in vitro and in vivo.
• Toxicology & Safety Assessment: Employed as a quantitative standard in toxicokinetic studies and safety profiling of new chemical entities.

Basic Information

Product Name	p-Cresol Glucuronide Methyl Ester Triacetate
CAS No.	92420-85-4
Molecular Formula	C₂₁H₂₆O₁₁
Molecular Weight	454.42 g/mol
Synonyms	4-Methylphenyl β-D-Glucopyranosiduronic Acid Methyl Ester Triacetate; p-Cresyl Glucuronide Methyl Ester Triacetate; 4-Cresol Glucuronide Methyl Ester Triacetate; (2R,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-((4-methylphenoxy)methoxy)tetrahydro-2H-pyran-2-carboxylic Acid Methyl Ester; Methyl (tri-O-acetyl-β-D-glucopyranosyluronate) 4-methylphenyl Ether
EINECS	Contact for details

Quality Control

Every batch of p-Cresol Glucuronide Methyl Ester Triacetate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol includes chromatographic purity verification by HPLC and structural confirmation by NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.