Description

Cyclo(L-Abu-L-Orn-L-Leu-D-Phe-L-Pro-L-Abu-L-Orn-L-Leu-D-Phe-L-Pro-) is a complex cyclic decapeptide featuring a unique sequence of amino acids, including L-α-aminobutyric acid (Abu), L-ornithine (Orn), L-leucine (Leu), D-phenylalanine (D-Phe), and L-proline (Pro). This specific structural architecture is of significant interest for advanced research and development in peptide-based pharmaceuticals and biochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, structure-activity relationship (SAR) studies, and the development of novel therapeutic agents. The compound, identified by CAS No. 92278-13-2, requires careful handling due to its specialized nature.

Application

• Pharmaceutical Research & Drug Discovery: Serves as a key intermediate or lead compound in the development of novel peptide-based therapeutics, including antimicrobials, hormone analogs, and enzyme inhibitors.
• Biochemical Research: Used as a model compound to study peptide cyclization, conformational stability, and receptor-ligand interactions in academic and industrial laboratories.
• Structure-Activity Relationship (SAR) Studies: The specific incorporation of D-amino acids (D-Phe) and unusual residues (Orn, Abu) makes it valuable for probing the impact of stereochemistry and side-chain properties on biological activity.
• Peptide Library Synthesis: Can be used as a scaffold or template for generating focused libraries to screen for new bioactive molecules.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in peptide analysis using HPLC and LC-MS.

Basic Information

Product Name	Cyclo(L-Abu-L-Orn-L-Leu-D-Phe-L-Pro-L-Abu-L-Orn-L-Leu-D-Phe-L-Pro-)
CAS No.	92278-13-2
Molecular Formula	C58H88N14O12
Molecular Weight	1173.4 g/mol
Synonyms	Cyclo(Abu-Orn-Leu-D-Phe-Pro-Abu-Orn-Leu-D-Phe-Pro); Cyclic Decapeptide (Abu, Orn, Leu, D-Phe, Pro)2; c[Abu-Orn-Leu-D-Phe-Pro-Abu-Orn-Leu-D-Phe-Pro]; Cyclo(L-α-aminobutyryl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-α-aminobutyryl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl); 92278-13-2 (CAS Registry Number); Cyclo(Abu-Orn-Leu-D-Phe-Pro)2
EINECS	Contact for details

Quality Control

Our Cyclo(L-Abu-L-Orn-L-Leu-D-Phe-L-Pro-L-Abu-L-Orn-L-Leu-D-Phe-L-Pro-) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA) to ensure structural fidelity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.