Description

1-(Hydroxy(Phenyl)Methyl)Cyclopropanecarbonitrile is a versatile and synthetically valuable chiral building block featuring both a cyclopropane ring and a benzylic nitrile group. This compound matters as a key intermediate in the pharmaceutical and agrochemical industries, enabling the construction of complex molecular architectures with high stereochemical control. It is primarily needed by research chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs), advanced agrochemicals, and novel materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the stability and reactivity of the cyclopropane moiety.
• Asymmetric Catalysis: Serves as a precursor or ligand in asymmetric synthesis to induce chirality in target molecules.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fine chemicals and specialty materials.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	1-(Hydroxy(Phenyl)Methyl)Cyclopropanecarbonitrile
CAS No.	92242-15-4
Molecular Formula	C11H11NO
Molecular Weight	173.21 g/mol
Synonyms	α-Cyclopropylmandelonitrile; (Cyclopropyl)(hydroxy)(phenyl)acetonitrile; 1-(Hydroxyphenylmethyl)cyclopropanecarbonitrile; (RS)-1-(Hydroxy(phenyl)methyl)cyclopropanecarbonitrile; (±)-1-(Hydroxy(phenyl)methyl)cyclopropanecarbonitrile; Cyclopropanecarbonitrile, 1-(hydroxy(phenyl)methyl)-; Benzeneacetonitrile, α-cyclopropyl-α-hydroxy-
EINECS	Contact for details

Quality Control

Our 1-(Hydroxy(Phenyl)Methyl)Cyclopropanecarbonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and chiral integrity where applicable. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary to prevent moisture uptake and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.