Description

(S)-Boc-3-Amino-2-Pyrrolidinone CAS NO 92235-34-2 is a high-purity, chirally pure building block featuring a protected amino group and a lactam ring, making it a versatile intermediate for complex organic synthesis. Its primary value lies in enabling the efficient and stereoselective construction of pharmacologically active molecules, particularly those targeting the central nervous system. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries working on novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potent γ-aminobutyric acid (GABA) analogs and other neuroactive compounds.
• API Development: Used in the research and scale-up production of new chemical entities (NCEs) for treating epilepsy, neuropathic pain, and anxiety disorders.
• Asymmetric Synthesis: Serves as a precursor for introducing the (S)-configured 3-aminopyrrolidinone moiety into complex molecular architectures.
• Peptidomimetics & PROTACs: Incorporated into the design of protease inhibitors and proteolysis-targeting chimeras (PROTACs) due to its lactam scaffold.
• Agrochemical Research: Potential intermediate for developing chiral active ingredients with specific biological activity.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic synthesis and process optimization.

Basic Information

Product Name	(S)-Boc-3-Amino-2-Pyrrolidinone
CAS No.	92235-34-2
Molecular Formula	C9H16N2O3
Molecular Weight	200.24 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-3-amino-2-pyrrolidinone; (S)-3-Amino-1-Boc-2-pyrrolidinone; (S)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidin-2-one; (S)-N-Boc-3-aminopyrrolidin-2-one; (3S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-aminopyrrolidin-2-one; tert-Butyl (S)-(2-oxo-3-pyrrolidinyl)carbamate; (S)-Boc-3-Aminopyrrolidin-2-one
EINECS	Contact for details

Quality Control

Our (S)-Boc-3-Amino-2-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.