Description

(3-(n-Hydroxy)Carboxamido-2-Benzylpropanoyl)Glycine is a specialized organic compound featuring a glycine moiety linked to a complex benzylpropanoyl structure with a hydroxamic acid functional group. This unique molecular architecture makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by research chemists and process development scientists in the fine chemical and pharmaceutical industries for its role in creating novel bioactive compounds and potential drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting enzymatic pathways where the hydroxamic acid group acts as a metal-chelating pharmacophore.
• Protease Inhibitor Research: Used in the development of inhibitors for metalloproteases (e.g., matrix metalloproteinases, histone deacetylases) due to its potent zinc-binding hydroxamate group.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating activity-based probes and affinity tags to study enzyme function and protein interactions.
• Peptidomimetic Synthesis: Employed in the design and construction of peptidomimetics, where it can replace natural amino acids to enhance metabolic stability and bioavailability.
• Fine Chemical Synthesis: Acts as a sophisticated chiral synthon for the asymmetric synthesis of complex natural products and other high-value specialty chemicals.
• Bioconjugation Chemistry: The carboxylic acid and hydroxamic acid functionalities provide handles for conjugation to biomolecules, polymers, or surfaces for various biotechnological applications.

Basic Information

Product Name	(3-(n-Hydroxy)Carboxamido-2-Benzylpropanoyl)Glycine
CAS No.	92175-56-9
Molecular Formula	C13H16N2O5
Molecular Weight	280.28 g/mol
Synonyms	N-[(Benzyloxycarbonyl)amino]-2-(hydroxyamino)-2-oxoethyl-L-phenylalanine; Z-Asp(OHu)-Gly-OH; (2S)-2-[[(2S)-2-Benzyl-3-[(hydroxyamino)carbonyl]propanoyl]amino]acetic Acid; N-[(Benzyloxycarbonyl)-L-aspartyl]glycine Hydroxamate; L-Aspartic acid, N-[(benzyloxycarbonyl)-, 1-(hydroxyamino)-1-oxo-3-(phenylmethyl)propyl] ester; Aspartylglycine hydroxamate derivative; Z-Aspartylglycine hydroxamic acid
EINECS	Contact for details

Quality Control

Our (3-(n-Hydroxy)Carboxamido-2-Benzylpropanoyl)Glycine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from advanced techniques like HPLC, NMR, and mass spectrometry. Specifications can be tailored to meet the stringent requirements of cGMP for pharmaceutical intermediates and other research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.