Description

(E)-Ceftriaxone CAS NO 92143-31-2 is a critical third-generation cephalosporin antibiotic, specifically the E-isomer of ceftriaxone, valued for its broad-spectrum activity against Gram-positive and Gram-negative bacteria. Its primary importance lies in serving as a key pharmaceutical intermediate and reference standard for the research, development, and quality control of advanced antibacterial drugs. This high-purity compound is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and analytical chemistry sectors who require a reliable and well-characterized raw material for API synthesis and analytical applications.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for injectable antibiotic formulations.
• Reference Standard: Serves as a high-purity chemical standard for quality control (QC) and assurance in pharmaceutical manufacturing, ensuring batch consistency.
• Research & Development: Utilized in microbiological and pharmacological studies to investigate antibiotic efficacy, resistance mechanisms, and new drug combinations.
• Analytical Applications: Employed in HPLC, LC-MS, and other chromatographic methods for method development, validation, and testing.
• Biochemical Research: Applied in studies exploring bacterial cell wall synthesis inhibition and the structure-activity relationships of β-lactam antibiotics.

Basic Information

Product Name	(E)-Ceftriaxone
CAS No.	92143-31-2
Molecular Formula	C18H18N8O7S3
Molecular Weight	554.58 g/mol
Synonyms	(E)-Ceftriaxone; Ceftriaxone E-isomer; (6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Ro 13-9904 (E-isomer); Antibiotic Ro 13-9904 E-isomer
EINECS	Contact for details

Quality Control

Our (E)-Ceftriaxone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade specifications suitable for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment and sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.