Description

Tosyl-D-Asparagine CAS NO 92142-18-2 is a high-purity, protected amino acid derivative where the amine functionality of D-asparagine is safeguarded by a tosyl group. This compound is critically important as a key chiral building block and intermediate in sophisticated organic synthesis, particularly for the production of peptides and peptidomimetics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and advanced biochemical research.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected D-asparagine residue in solid-phase and solution-phase peptide synthesis to construct peptides with specific stereochemistry.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor in research exploring amino acid metabolism and protein function.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in catalytic asymmetric reactions to introduce chiral centers into target molecules.
• Proteomics & Diagnostics: Utilized in the development of specialized reagents, labeled probes, and standards for analytical and diagnostic applications.
• Academic & R&D Laboratories: A fundamental reagent for synthetic organic chemistry research, supporting the discovery of new chemical entities and methodologies.

Basic Information

Product Name	Tosyl-D-Asparagine
CAS No.	92142-18-2
Molecular Formula	C11H14N2O5S
Molecular Weight	286.30 g/mol
Synonyms	D-2-[(4-Methylphenyl)sulfonyl]amino]-4-carbamoylbutanoic Acid; N-(p-Toluenesulfonyl)-D-asparagine; N-Tosyl-D-asparagine; D-Asparagine, N-tosyl-; (R)-2-((4-Methylphenyl)sulfonamido)succinamic Acid; Tosyl-D-Asp-OH; p-Toluenesulfonyl-D-asparagine
EINECS	Contact for details

Quality Control

Our Tosyl-D-Asparagine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.