Description

n-Boc-Propargylamine is a versatile and high-purity protected amine building block, essential for advanced organic synthesis and pharmaceutical research. Its primary value lies in the orthogonal protection of the amine group by the tert-butoxycarbonyl (Boc) moiety, which allows for selective reactions at the propargyl functionality. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures, particularly in click chemistry and peptide mimetic development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially those incorporating alkyne handles for bioconjugation.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) to introduce propargylglycine derivatives or other non-natural amino acid residues with protected amines.
• Click Chemistry: Serves as a fundamental substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole linkages in polymers, dendrimers, and bioconjugates.
• Agrochemical Synthesis: Intermediate in the production of specialized herbicides, fungicides, and plant growth regulators that require propargylamine scaffolds.
• Material Science: Monomer or cross-linking agent for synthesizing functional polymers, coatings, and advanced materials with tailored properties.
• Bioconjugation Probes: Facilitates the labeling of biomolecules (proteins, antibodies, nucleic acids) with fluorescent dyes or other tags via its alkyne group.
• Chemical Biology Research: Tool compound for developing activity-based probes and studying enzyme mechanisms through targeted inhibition or labeling.
• Academic & R&D: Fundamental reagent in university and corporate research laboratories for methodological development in synthetic organic chemistry.

Basic Information

Product Name	n-Boc-Propargylamine
CAS No.	92136-39-5
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	N-(tert-Butoxycarbonyl)propargylamine; 2-Propyn-1-amine, N-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl (2-propynyl)carbamate; Boc-Propargylamine; N-Boc-2-propynylamine; N-Boc-propargylamine; (Prop-2-yn-1-yl)carbamic acid tert-butyl ester; Propargylamine, N-Boc-protected
EINECS	Contact for details

Quality Control

Our n-Boc-Propargylamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided with every shipment and are available upon request. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can compromise product integrity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.