Description

Proline, 1-(Trifluoroacetyl)- (9Ci) is a protected amino acid derivative, specifically a trifluoroacetylated form of L-proline. This compound is a crucial building block in advanced organic synthesis, particularly in peptide chemistry and medicinal chemistry, where it serves as a key intermediate for introducing the proline scaffold with orthogonal protecting group strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of peptide-based drugs and peptidomimetics, enabling the incorporation of proline residues.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of protease inhibitors and other targeted therapies.
• Peptide Synthesis: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS), where the trifluoroacetyl group offers selective deprotection capabilities.
• Chemical Biology Probes: Employed in the creation of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Potential intermediate in the synthesis of novel, bioactive compounds for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	Proline, 1-(Trifluoroacetyl)- (9Ci)
CAS No.	92076-93-2
Molecular Formula	C7H8F3NO3
Molecular Weight	211.14 g/mol
Synonyms	1-(Trifluoroacetyl)-L-proline; L-Proline, 1-(trifluoroacetyl)-; N-Trifluoroacetyl-L-proline; N-TFA-L-proline; (S)-1-(Trifluoroacetyl)pyrrolidine-2-carboxylic acid; 2-Pyrrolidinecarboxylic acid, 1-(trifluoroacetyl)-, (S)-; Trifluoroacetic acid L-proline anhydride; N-α-Trifluoroacetyl-L-proline
EINECS	Contact for details

Quality Control

Our Proline, 1-(Trifluoroacetyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications for trace solvents and impurities, ensuring compliance with research and development standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.