Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetrayl-Tetrakis(Methylphosphonic Acid) is a highly functionalized macrocyclic ligand, specifically a phosphonate derivative of cyclen (1,4,7,10-tetraazacyclododecane). This compound is valued for its exceptional chelating properties, forming stable complexes with a wide range of metal ions, particularly lanthanides and transition metals. It is primarily utilized in advanced research and industrial applications requiring precise metal coordination, such as in the development of MRI contrast agents, radiopharmaceuticals, and catalysts. Our supply ensures high-purity material critical for reproducible results in sensitive chemical synthesis and biomedical applications.

Application

• MRI Contrast Agent Precursor: A key intermediate in the synthesis of next-generation gadolinium-based contrast agents for magnetic resonance imaging (MRI).
• Radiopharmaceutical Chelator: Used to stably bind radioactive isotopes (e.g., Gallium-68, Lutetium-177) for targeted cancer diagnosis and therapy (theranostics).
• Catalysis Research: Serves as a sophisticated ligand framework for designing homogeneous catalysts in organic synthesis and polymerization processes.
• Metal Scavenging & Decontamination: Employed in environmental and analytical chemistry for the selective removal or detection of heavy metal ions.
• Material Science: Used in the surface functionalization of nanoparticles and the creation of metal-organic frameworks (MOFs) with specific properties.
• Chemical Sensing: Acts as a receptor component in the development of fluorescent or colorimetric sensors for metal cations.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetrayl-Tetrakis(Methylphosphonic Acid)
CAS No.	91987-74-5
Molecular Formula	C16H40N4O12P4
Molecular Weight	664.41 g/mol
Synonyms	DOTP; Tetraazacyclododecane tetramethylenephosphonic acid; Cyclen-tetramethylphosphonic acid; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonic acid); Tetrakis(methylphosphonic acid)-cyclen; H8DOTP; DOTP (chelator); 1,4,7,10-Tetrakis(methylphosphonylmethyl)-1,4,7,10-tetraazacyclododecane
EINECS	Contact for details

Quality Control

Our production of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetrayl-Tetrakis(Methylphosphonic Acid) adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with your specific research or development requirements. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and kept in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.