Description

[2-(Trimethylammonium)Ethyl]Methanethiosulfonate Bromide is a specialized, high-purity chemical reagent primarily used as a sulfhydryl-reactive alkylating agent for protein modification and bioconjugation. This compound is critical for researchers and manufacturers requiring precise, site-specific labeling of cysteine residues in peptides, proteins, and other biomolecules. It is essential for applications in pharmaceutical research, proteomics, and the development of diagnostic assays and antibody-drug conjugates (ADCs).

Application

• Protein and Antibody Modification: Site-specific conjugation of fluorescent dyes, biotin, or other functional groups to cysteine residues for analytical and therapeutic purposes.
• Bioconjugation for ADC Development: A key reagent in the linker-payload chemistry for constructing stable and efficacious Antibody-Drug Conjugates.
• Proteomics Research: Used to introduce stable isotopic labels or affinity tags for mass spectrometry-based protein quantification and interaction studies.
• Enzyme Activity Studies: Selective blocking or modification of active-site thiol groups to study enzyme mechanism and function.
• Surface Immobilization: Functionalization of gold surfaces or nanoparticles via thiol-gold chemistry for biosensor and diagnostic device fabrication.
• Cross-linking Agent: For introducing reversible or cleavable cross-links between biomolecules in structural biology.

Basic Information

Product Name	[2-(Trimethylammonium)Ethyl]Methanethiosulfonate Bromide
CAS No.	91774-25-3
Molecular Formula	C6H16BrNO2S2
Molecular Weight	278.23 g/mol
Synonyms	MTSET Bromide; (2-Trimethylammoniumethyl) Methanethiosulfonate Bromide; 2-(Trimethylammonio)ethyl methanethiosulfonate bromide; MTSEA+; [2-(Trimethylamino)Ethyl]Methanethiosulfonate Bromide; Ammonium, (2-((methylsulfonyl)thio)ethyl)trimethyl-, bromide; Thiol-reactive alkylating agent MTSET
EINECS	Contact for details

Quality Control

Our [2-(Trimethylammonium)Ethyl]Methanethiosulfonate Bromide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant cGMP and ISO guidelines for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. Handle and store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.