Description

(S)-1-Boc-2-Acetyl-Pyrrolidine is a high-purity, chiral building block essential for advanced organic synthesis. This compound is a critical intermediate in the development of active pharmaceutical ingredients (APIs) and complex bioactive molecules, offering a protected amine and a reactive ketone for selective functionalization. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of peptidomimetics and other nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetics & Proline Derivatives: Serves as a protected proline analog for constructing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Used as a starting material or auxiliary in stereoselective reactions to introduce chiral centers into complex molecular architectures.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for commercial API manufacturing under GMP guidelines.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of enzyme inhibitors, molecular probes, and labeled compounds for biochemical studies.
• Agrochemical Research: Acts as an intermediate in the synthesis of novel chiral pesticides and herbicides.

Basic Information

Product Name	(S)-1-Boc-2-Acetyl-Pyrrolidine
CAS No.	91550-08-2
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-2-acetylpyrrolidine; (S)-2-Acetyl-1-Boc-pyrrolidine; (S)-N-Boc-2-acetylpyrrolidine; 1-Boc-2-acetyl-(S)-pyrrolidine; tert-Butyl (S)-2-acetylpyrrolidine-1-carboxylate; (S)-1-(tert-Butyloxycarbonyl)-2-acetylpyrrolidine; (S)-1-Boc-2-acetylpyrrolidine; 2-Acetyl-1-[(2-methyl-2-propanyl)oxycarbonyl]-(S)-pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-2-Acetyl-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.