Description

Demethyl Naproxen Acyl-β-D-Glucuronide is a high-purity metabolite reference standard critical for pharmaceutical research and development. This compound is essential for conducting accurate analytical studies, including method development, validation, and bioanalytical testing. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in pharmacokinetics, drug metabolism, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of naproxen metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, bioavailability, and clearance of naproxen and related compounds.
• Bioanalytical Method Development: Critical for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS assays for metabolite detection and quantification.
• Impurity Profiling and Characterization: Employed as a known impurity or degradation product standard to ensure drug substance and product purity per ICH guidelines.
• Toxicology and Safety Assessment: Supports studies aimed at understanding the safety profile and potential toxicity of metabolic byproducts.
• Clinical Research: Used in studies monitoring patient metabolite levels for pharmacokinetic profiling and personalized medicine approaches.

Basic Information

Product Name	Demethyl Naproxen Acyl-β-D-Glucuronide
CAS No.	91488-21-0
Molecular Formula	C22H24O10
Molecular Weight	448.42 g/mol
Synonyms	O-Desmethyl Naproxen Acyl Glucuronide; 6-O-Desmethyl Naproxen Acyl-β-D-Glucuronide; Demethylnaproxen Glucuronide; Naproxen Metabolite Glucuronide; (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid β-D-glucopyranosiduronic acid (demethyl analog); 2-(6-Hydroxy-2-methoxynaphthalen-1-yl)propanoic acid β-D-glucuronide; DMN-AG; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Demethyl Naproxen Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.