Description

4,5-Dimethoxy-2-Fluorobenzyl Chloride is a versatile and high-value fluorinated benzyl chloride derivative. This compound serves as a critical pharmaceutical intermediate and organic synthesis building block, enabling the introduction of a reactive chloromethyl group into complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorinated benzyl moiety enhances biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Cross-Coupling Reactions: The benzyl chloride group is reactive in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Functional Polymer Monomer: Employed to introduce fluorinated aromatic units into polymer chains, modifying thermal stability and chemical resistance.
• Chemical Research & Development: A valuable reagent in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	4,5-Dimethoxy-2-Fluorobenzyl Chloride
CAS No.	91407-48-6
Molecular Formula	C9H10ClFO2
Molecular Weight	204.63 g/mol
Synonyms	1-(Chloromethyl)-4,5-dimethoxy-2-fluorobenzene; 2-Fluoro-4,5-dimethoxybenzyl chloride; (4,5-Dimethoxy-2-fluorophenyl)methyl chloride; 4,5-Dimethoxy-2-fluorobenzylchloride; 91407-48-6; 2-Fluoro-4,5-dimethoxybenzylchloride; Benzene, 1-(chloromethyl)-4,5-dimethoxy-2-fluoro-
EINECS	Contact for details

Quality Control

Our 4,5-Dimethoxy-2-Fluorobenzyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to current Good Manufacturing Practice (GMP) principles where applicable. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring it meets the stringent requirements for pharmaceutical R&D and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.