Description

4-Ethynyl-1-Methylpiperidine is a versatile alkyne-functionalized piperidine derivative, a key building block in advanced organic synthesis. Its value lies in its unique molecular architecture, which combines a reactive terminal alkyne group with a sterically defined tertiary amine, enabling its use in click chemistry, ligand synthesis, and the construction of complex molecular frameworks. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and materials science who require reliable, high-quality building blocks for innovative applications.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in neurological and oncological research.
• Click Chemistry Reagent: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition reactions with azides for bioconjugation and polymer functionalization.
• Ligand and Catalyst Precursor: Used in the synthesis of specialized nitrogen-containing ligands for transition metal catalysis and asymmetric synthesis.
• Agrochemical Research: Serves as a building block for developing new crop protection agents and herbicides.
• Material Science: Incorporated into monomers and polymers to modify thermal, mechanical, or electronic properties.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological systems and enzyme activity.

Basic Information

Product Name	4-Ethynyl-1-Methylpiperidine
CAS No.	91324-39-9
Molecular Formula	C8H13N
Molecular Weight	123.20 g/mol
Synonyms	1-Methyl-4-ethynylpiperidine; 4-Ethynyl-1-methylpiperidine; 1-Methyl-4-piperidinylacetylene; 4-Ethynyl-N-methylpiperidine; N-Methyl-4-ethynylpiperidine; 4-(Ethynyl)-1-methylpiperidine; 1-Methyl-4-(ethynyl)piperidine
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-1-Methylpiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.