Description

Substance P (5-11), Arg(5)-Trp(7,9)-Nle(11)- is a bioactive peptide fragment derived from the neuropeptide Substance P. This specific analog is engineered for enhanced stability and receptor selectivity, making it a critical tool for advanced neuroscience and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers investigating neurokinin receptor signaling, pain pathways, and inflammatory responses.

Application

• Neuroscience Research: Used as a selective neurokinin-1 (NK1) receptor agonist to study the role of Substance P in pain transmission, neuroinflammation, and central nervous system disorders.
• Pharmacological Assay Development: Serves as a reference standard and active agent in high-throughput screening (HTS) for drug discovery programs targeting NK1 receptors.
• Cell Signaling Studies: Applied in vitro to stimulate and analyze intracellular signaling cascades, calcium mobilization, and gene expression related to neuropeptide activity.
• Biochemical Reagent: Employed in receptor binding assays, antibody production, and as a calibrant in analytical method development (e.g., HPLC, LC-MS).
• Academic & Preclinical Research: Supports fundamental research into migraine, depression, nausea, and other conditions modulated by tachykinin pathways.

Basic Information

Product Name	Substance P (5-11), Arg(5)-Trp(7,9)-Nle(11)-
CAS No.	91234-81-0
Molecular Formula	C48H68N16O8
Molecular Weight	981.2 g/mol
Synonyms	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (5-11 fragment analog); [Arg5, Trp7,9, Nle11]-Substance P (5-11); Substance P fragment 5-11 analog; NK1 receptor agonist peptide; Neurokinin receptor ligand; SP (5-11) analog; [pGlu5, MePhe8, Sar9]-Substance P (5-11) (common research variant)
EINECS	Contact for details

Quality Control

Our Substance P (5-11) analog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, lyophilized powder is recommended. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Solutions should be prepared in appropriate buffers and used immediately or stored aliquoted at -80°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.