Description

(S)-n-α-T-Butyloxycarbonyl-Pyroglutamic Acid T-Butyl Ester is a high-purity, chiral protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block in the production of complex peptides and pharmaceutical intermediates, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected glutamic acid derivative to prevent unwanted side reactions.
• Proteomics Research: Serves as a reagent in biochemical research for studying protein structure and function.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecules.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening in drug discovery programs.
• Bioconjugation: Can be used to modify peptides or proteins for diagnostic or therapeutic applications.

Basic Information

Product Name	(S)-n-α-T-Butyloxycarbonyl-Pyroglutamic Acid T-Butyl Ester
CAS No.	91229-91-3
Molecular Formula	C₁₄H₂₃NO₆
Molecular Weight	301.34 g/mol
Synonyms	(S)-5-Oxo-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid tert-butyl ester; Boc-L-pyroglutamic acid tert-butyl ester; (S)-1-Boc-5-oxopyrrolidine-2-carboxylic acid t-butyl ester; (S)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid tert-butyl ester; Boc-L-pyroGlu-OtBu; (S)-N-Boc-pyroglutamic acid t-butyl ester; L-Pyroglutamic acid, N-Boc-, tert-butyl ester; (S)-N-(tert-Butoxycarbonyl)-5-oxoproline tert-butyl ester
EINECS	Contact for details

Quality Control

Our (S)-n-α-T-Butyloxycarbonyl-Pyroglutamic Acid T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric excess, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.