Description

Hemoglobin Aichi CAS NO 91117-28-1 is a specific, naturally occurring variant of human hemoglobin, characterized by a point mutation in the globin chain. This biochemical reference standard is critical for research and diagnostic applications where precise molecular characterization is required. It is primarily utilized by clinical research laboratories, diagnostic kit manufacturers, and academic institutions studying hemoglobinopathies and related blood disorders.

Application

• Clinical Diagnostics: Serves as a critical reference standard and control material in the development and calibration of diagnostic assays for detecting hemoglobin variants, such as in HPLC or capillary electrophoresis systems.
• Biomedical Research: Used as a model compound in studies investigating the structure-function relationships of hemoglobin, oxygen affinity, and the pathophysiology of rare hemoglobinopathies.
• Quality Control in IVD Manufacturing: Essential for the quality assurance and validation processes of in-vitro diagnostic (IVD) devices and reagents designed for hemoglobin analysis.
• Hematology Studies: Employed in academic and industrial research settings to understand the biochemical and biophysical properties of mutant hemoglobins and their clinical significance.
• Calibration Standards: Acts as a high-purity calibrant for advanced analytical instrumentation, ensuring accurate identification and quantification of hemoglobin Aichi in patient samples.

Basic Information

Product Name	Hemoglobin Aichi
CAS No.	91117-28-1
Molecular Formula	C2952H4664N812O840S16Fe4 (Human HbA α2β2 tetramer, mutant)
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Aichi; Hemoglobin Aichi variant; α2β290 (FG2) Lys→Glu; Hemoglobin with mutation β90(FG2)Lys→Glu; HBA1_HUMAN variant; Deoxyhemoglobin Aichi; Oxyhemoglobin Aichi; Methemoglobin Aichi
EINECS	Contact for details

Quality Control

Our Hemoglobin Aichi is produced and handled under stringent quality protocols suitable for research and diagnostic use. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), spectral properties, and physical state is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or frozen solution
Identification (IR / UV-Vis)	Conforms to reference spectrum
Purity (HPLC)	≥ 95% (Hemoglobin Aichi variant)
Assay (Functional)	Contact for details
Methemoglobin Content	< 5%
Solubility	Clear solution in buffer (specified)
Endotoxin	< 1.0 EU/mg (where applicable)
Protein Concentration	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.