Description

Boc-D-Ala-OMe is a protected amino acid derivative, specifically the methyl ester of N-tert-butoxycarbonyl-D-alanine. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering high stereochemical purity and stability for demanding applications. It is primarily utilized by pharmaceutical R&D teams, process chemists, and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs), peptide-based therapeutics, and advanced research compounds.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for introducing the D-alanine residue with orthogonal N-terminal protection.
• Pharmaceutical Intermediates: Serves as a critical chiral synthon in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Used in the preparation of modified peptides for biochemical probes, diagnostic tools, and drug delivery systems.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: Fundamental building block for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	Boc-D-Ala-OMe
CAS No.	91103-47-8
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-alanine methyl ester; Methyl N-Boc-D-alaninate; (R)-Methyl 2-((tert-butoxycarbonyl)amino)propanoate; Boc-D-Alanine methyl ester; BOC-D-ALA-OME; D-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; tert-Butyloxycarbonyl-D-alanine methyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Ala-OMe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation. A Certificate of Analysis (COA) detailing specifications and test results is supplied with each batch to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Melting Point	78 - 82 °C
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.