Description

(p-Amino-Phe6)-Angiotensin II is a chemically modified analog of the potent vasoconstrictor peptide hormone, Angiotensin II, featuring a para-amino substitution on the phenylalanine residue at position 6. This modification is crucial for research applications, particularly in the development of novel receptor ligands, enzyme inhibitors, and diagnostic tools within the field of cardiovascular and renal physiology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on the renin-angiotensin system (RAS).

Application

• Biochemical Research: Serves as a key reference standard and tool compound for studying Angiotensin II receptor (AT1 and AT2) binding affinity, specificity, and signaling pathways.
• Pharmaceutical Development: Used in the design and screening of novel antihypertensive drugs, receptor antagonists, and enzyme inhibitors targeting the RAS pathway.
• Diagnostic Reagent Synthesis: Acts as a precursor or hapten for developing immunoassays and diagnostic kits to measure renin-angiotensin system components.
• Enzyme Kinetics Studies: Employed as a substrate or inhibitor in assays for angiotensin-converting enzyme (ACE) and other proteases involved in peptide hormone metabolism.
• Structure-Activity Relationship (SAR) Analysis: The para-amino group provides a versatile handle for conjugation, enabling the creation of fluorescent, radioactive, or affinity-labeled probes for cellular and molecular imaging.
• Peptide Chemistry & Conjugation: The amino group facilitates cross-linking to carriers (e.g., BSA, KLH) for antibody production or to solid supports for affinity chromatography.

Basic Information

Item	Detail
Product Name	(p-Amino-Phe6)-Angiotensin II
CAS No.	90937-05-6
Molecular Formula	C50H71N13O12
Molecular Weight	1030.2 g/mol
Synonyms	p-Amino-Phenylalanine6-Angiotensin II; [p-NH2-Phe6]-Ang II; Asp-Arg-Val-Tyr-Ile-His-p-Amino-Phe-Pro-Phe; Angiotensin II (p-Amino-Phe6) analog; 1-L-Asparagine-5-L-valine-8-L-phenylalanine angiotensin II (p-amino-Phe6); A779 (Note: A779 is a closely related but distinct AT2 receptor antagonist; this compound is a precursor); Para-aminophenylalanine6-angiotensin II
EINECS	Contact for details

Quality Control

Every batch of (p-Amino-Phe6)-Angiotensin II is manufactured and analyzed under strict quality protocols to ensure the highest standards of purity and identity for research use. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, identity, and peptide content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.