Description

(n-Crotonyl)-(4S)-Isopropyl-2-Oxazolidinone CAS NO 90719-30-5 is a high-purity chiral auxiliary and building block used in asymmetric synthesis. Its value lies in enabling the stereoselective construction of complex molecules, which is critical for developing pharmaceuticals and fine chemicals with high enantiomeric purity. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality chiral reagents.

Application

• Asymmetric Aldol Reactions: As a chiral auxiliary for the Evans aldol reaction to install stereocenters with high diastereoselectivity.
• Pharmaceutical Intermediate Synthesis: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for β-lactam antibiotics and other chiral drugs.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Natural Product Synthesis: Facilitates the stereocontrolled synthesis of complex natural products and their analogs for biological screening.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable manufacturing routes for chiral compounds.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.

Basic Information

Item	Details
Product Name	(n-Crotonyl)-(4S)-Isopropyl-2-Oxazolidinone
CAS No.	90719-30-5
Molecular Formula	C10H15NO3
Molecular Weight	197.23 g/mol
Synonyms	(4S)-4-Isopropyl-3-[(2E)-but-2-enoyl]-1,3-oxazolidin-2-one; (S)-4-Isopropyl-3-crotonyl-2-oxazolidinone; (S)-3-Crotonyl-4-isopropyl-2-oxazolidinone; Evans Chiral Auxiliary (Crotonyl derivative); (S)-N-Crotonyl-4-isopropyl-2-oxazolidinone; (4S)-3-(trans-1-Oxo-2-butenyl)-4-(1-methylethyl)-2-oxazolidinone; (S)-3-(trans-Crotonyl)-4-isopropyl-2-oxazolidinone
EINECS	Contact for details

Quality Control

Our (n-Crotonyl)-(4S)-Isopropyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.