Description

(Tyr27)-Pth (27-48) (Human) is a synthetic peptide fragment corresponding to residues 27-48 of the human parathyroid hormone (PTH), with a tyrosine substitution at position 27. This compound is a critical research-grade biochemical tool for studying the structure, function, and signaling pathways of PTH, a key regulator of calcium and phosphate homeostasis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on metabolic bone diseases, endocrine disorders, and peptide-based drug discovery.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of PTH receptor binding, activation, and downstream signaling cascades.
• Drug Discovery & Development: Serves as a key intermediate or analog in the design and screening of novel therapeutics for osteoporosis, hyperparathyroidism, and hypoparathyroidism.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to detect and quantify PTH or related peptides in biological samples.
• Structure-Activity Relationship (SAR) Studies: Essential for investigating how specific amino acid modifications, like the Tyr27 substitution, affect the biological activity and stability of PTH fragments.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to examine the effects of PTH on osteoblast and osteoclast activity, renal function, and calcium metabolism.

Basic Information

Product Name	(Tyr27)-Pth (27-48) (Human)
CAS No.	90686-51-4
Molecular Formula	C₁₁₀H₁₇₃N₃₅O₃₃
Molecular Weight	~2560.8 g/mol
Synonyms	Parathyroid Hormone (27-48) (human, Tyr27-analog); PTH (27-48), [Tyr27]-; [Tyr27]-hPTH(27-48); hPTH(27-48) Tyr27 analog; Tyr27-PTH(27-48); PTH fragment 27-48 (Tyr27); Human parathyroid hormone fragment 27-48 (Tyr27-substituted)
EINECS	Contact for details

Quality Control

Our (Tyr27)-Pth (27-48) (Human) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to GMP principles for production and control, ensuring traceability and reliability for our global B2B clients in the life sciences sector.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.