Description

trans-4-Cyclohexyl-L-Proline Hydrochloride is a high-purity, non-proteinogenic amino acid derivative of significant importance in advanced pharmaceutical research and development. This chiral proline analog serves as a critical building block for the synthesis of complex bioactive molecules, particularly in the design of peptidomimetics and enzyme inhibitors. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers focused on drug discovery programs targeting metabolic and neurological disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and GPCR modulators.
• Peptidomimetic Design: Used to introduce conformational constraints and enhance metabolic stability in peptide-based therapeutic agents.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate reaction mechanisms and active site geometry.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in stereoselective synthesis.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	trans-4-Cyclohexyl-L-Proline Hydrochloride
CAS No.	90657-55-9
Molecular Formula	C11H20ClNO2
Molecular Weight	233.73 g/mol
Synonyms	(2S,4R)-4-Cyclohexylpyrrolidine-2-carboxylic acid hydrochloride; L-Proline, 4-cyclohexyl-, hydrochloride, (4R-trans)-; trans-4-Cyclohexyl-L-proline HCl; (4R)-4-Cyclohexyl-L-proline hydrochloride; 90657-55-9; (2S,4R)-4-Cyclohexyl-2-carboxypyrrolidinium chloride
EINECS	Contact for details

Quality Control

Our trans-4-Cyclohexyl-L-Proline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.