Description

Fmoc-His(Bum)-Oh CAS NO 90653-46-6 is a protected derivative of the amino acid histidine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers who require precise control over peptide chain assembly, particularly when incorporating histidine residues. It is an essential building block for the development of therapeutic peptides, diagnostic agents, and biochemical research tools in the pharmaceutical and biotechnology sectors.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of complex peptide sequences.
• Pharmaceutical Research: For the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Used in the preparation of peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Combinatorial Chemistry: A vital component in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Studies: Synthesis of custom peptides for studying protein-protein interactions, enzyme mechanisms, and structural biology.
• Diagnostic Reagent Development: Building block for peptides used in immunoassays, biosensors, and imaging probes.

Basic Information

Product Name	Fmoc-His(Bum)-Oh
CAS No.	90653-46-6
Molecular Formula	C27H29N3O5
Molecular Weight	475.54 g/mol
Synonyms	Fmoc-His(Bum)-OH; N-α-Fmoc-N-π-tert-butoxymethyl-L-histidine; Fmoc-L-histidine(N-π-Bum)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(1-((tert-butoxy)methyl)-1H-imidazol-4-yl)propanoic acid; Fmoc-His(Bum)-OH; Fmoc-His(Bum); N-α-(9-Fluorenylmethoxycarbonyl)-N-π-(tert-butoxymethyl)-L-histidine
EINECS	Contact for details

Quality Control

Our Fmoc-His(Bum)-Oh is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.